Innovative Topical Therapies for Treating Inflamed and Infectious Oral Tissues.

The company’s mission has been to develop the first non-antibiotic line of products that can halt the advancement of infectious conditions common with periodontal disease, acute and chronic non-healing skin wounds.  The success of our technology platform, called Desiccation Shock Technology, is paving the way to safely and effectively reverse these infectious conditions by eliminating harmful bacteria on contact.


EPIEN Medical’s products have passed rigorous clinical trials and are cleared as medical devices for patient use.


HYBENX is the company’s first product introduction into the dental market that safely and effectively eliminates necrotic debris and bacteria.  This action restores infectious oral tissue to a healing state.

HYBENX® is a topical therapeutic liquid. It is intended for use in the oral cavity as an adjunctive agent to enhance the debridement and decontamination of necrotizing tissues during standard dental procedures to facilitate healing and reduce patient discomfort.

A typical application of HYBENX® begins with layering, or irrigating, varying amounts, usually less than one milliliter, directly onto the surface of the oral tissue, such as a periodontal pocket. The product is typically left in place for 10 – 30 seconds then is removed with a water rinse. Detailed procedural instructions are provided in the IFU.

HYBENX® can be characterized by its functionality as clinical tool that was designed to perform controlled, intense, instantaneous water extraction from the topmost layer of necrotized tissue on a lesion surface. HYBENX® essentially is a therapeutic instrument used to instantaneously convert necrotized tissues, microbial biofilm and other proinflammatory pathogenic substances on the surface of an oral lesion into harmless devitalized tissue coagulum whenever and wherever that would be beneficial. It is expected that users of HYBENX® will adapt specific application techniques to best fit their own treatment protocols to provide the greatest clinical benefit possible to their patients.

In order to clearly demonstrate the entire mechanism of action of HYBENX®, it is helpful to regard it as consisting of three separate concurrent processes and to discuss each process separately. The first is the process by which HYBENX® extracts water from tissue surfaces leading to tissue surface desiccation. The second is the process by which the tissue surface desiccation leads to formation of tissue surface coagulum. The third is the process by which the formation of the tissue surface coagulum provides clinical benefits.


HYBENX forges the pathway to eradicate plaque (biofilm) and restore oral tissues to their normal state (anatomy).

What is Periodontitis? 

Periodontitis is a gum disease.  It is a chronic inflammatory disease that is triggered by bacterial microorganisms and involves a severe chronic inflammation that causes the destruction of the tooth-supporting apparatus and can lead to tooth loss. It can also lead to other health problems.

Where Can I Purchase HYBENX in the US? 

EPIEN Medical is proud to have partnered with many of the very best dental distribution companies in the United States. We have partnered with all 3 of the national full service distribution companies, as well as many of the outstanding regional dealers. Feel free to reach out to us if you would like to know if your dealer of choice is currently a distributor, or ask your local distributor rep. We are excited to bring you this outstanding product, and proud to be working with so many fantastic companies who support you.


DEBACTEROL® Canker Sore Pain Relief is a liquid, topical, debriding agent used for treating ulcerating oral mucosal lesions, commonly referred to as canker sores, aphthous ulcers, or oral ulcers, as well as minor oral abrasions. DEBACTEROL has unique chemical and physical properties that are particularly beneficial whenever a dental or medical procedure in the mouth requires controlled, limited debridement of necrotic or damaged tissues.

DEBACTEROL® is prescription treatment for Aphthous Stomatitis that completely stops oral ulcer pain, seals damaged oral mucosal tissues, and forms a protective barrier after just one application.

DEBACTEROL® is sold in the United States by prescription only.

For more information, please visit the DEBACTEROL website »


ORALMEDIC® Barrier Solution

ORALMEDIC is currently unavailable. For more information contact: