Peer Reviewed Papers

Exploring Mechanisms of Biofilm Removal K. Sahni, et al. Dentistry 2016 6:4

A Histologic Assessment of a HYBENX Oral Tissue Decontaminant in Vital Pulp Therapy in Dogs M. Rohrer et al. J of Bio Reg & Homeo Agents Vol.30, no.2(S1), 189-187(2016).

Assessing the Dynamic Biofilm Removal of Sulfonated Phenolics using CP-OCT R. Jones, et al. Lasers in Dentistry Vol.10044(207).

Influence of Dentin and Enamel Pretreatment with Acidic Sulfur Compounds on Adhesive Performance A. Ioannidis, et al. Clin Oral Invest (2013) 17:1885-1892

The Use of Molecular Biology Methods to Evaluate the Activity of Different Topical Treatments Against Periodontal Pathogen Bacteria 

Alessia Pardo, Salma Hamzaoui, Annarita Signoriello, Elena Messina, Maria del Mar Lleo, Gloria Burlacchini, Andrea Butera, Andera Scribantem, Giorgio Lombardo, and Caterina Signoretto 

Microbiological and Clinical Evaluation of the Efficacy of a Chemical Desiccant Agent in Non-Surgical Periodontal Treatment: A Randomized Controlled Clinical Trial
Alessia Pardo, Gabriele Brancato, Annarita Signoriello, Elena Messina , Giovanni Corrocher,
Valentina Bellopede, Gloria Burlacchini, Caterina Signoretto and Giorgio Lombardo

A Local Desiccant Antimicrobial Agent as an Alternative to Adjunctive Antibiotics in the Treatment of Periodontitis: A Narrative Review. Iulia C. Micu, et al. National Library of Medicine, Feb 24, 2023. 10.0090/antibiotics 12030456

The effects of adjunctive use of a desiccant agent in the treatment of stage III periodontitis (Randomized controlled clinical trial) Khalil, et al Saudi Dental Journal January 2023.

Pilot Evaluation of a Simple Adjunctive Method for Improved Removal of Oral Biofilm during Conventional Scaling and Root Planing Therapy J. Bracke, et al J of Bio Reg & Homeo Agents Vol.29, no.3(S1), 6-9 (2015).

The effects of a desiccant agent in the treatment of chronic periodontitis: a randomized, controlled clinical trial G. Isola, et al. Clin Oral Invest17 June 2017.

The Efficacy of HYBENX® Oral Tissue Decontaminant for Periodontal Disease Treatment: A Case Series Study L. Dorina, et al. Int J of Adv in Case Reports, 2015;2(7):405-408.

Full-mouth ultrasonic debridement in association with HYBENX® Oral Tissue Decontaminant as an initial approach to the treatment of chronic periodontitis G. Lombardo, et al. Quint Int Perio 28(3) 5-14. 2012.

A topical desiccant agent in association with the ultrasonic debridement in the initial treatment of chronic periodontitis: a clinical and microbiological study. G. Lombardo, et al. New Microbio 38(3): 393-407.2015.

Treatment of Acute Periodontal Abscesses using the Biofilm Decontamination Approach. A Case Report Study. G. Pini-Prato, et al. Int J Periodontics Restor Dent. 36(1): 55-63.2016.

Antimicrobial Effects of a Root Canal Cleanser in Treating Contaminated Implants: Ex Vivo Study. Z. Rifkin, et al. IADR Poster Session. Boston. 2012.

The biofilm decontamination approach for treatment of periodontal abscess and peri-implantitis. E. Mancini, et al. Rev Asoc Odontol Argent 2016;104:79-85.

Nonsurgical Treatment of Peri-implantitis Using the Biofilm Decontamination Approach: A Case Report Study. G.Pini-Prato, et al. Int J Periodontics Restorative Dent. 36(3): 383-391.2016.

Anti-infective Efficacy of Mechanical Debridement with Adjunctive Modalities on Clinical and Cytokine Parameters in Treatment of Chronic Periodontitis: Randomized Control Clinical Trial. Rajagopal A, Varghese J, Bhat V, Acharya V, Kamath V. Anti-infective Efficacy of Mechanical Debridement with Adjunctive Modalities on Clinical and Cytokine Parameters in Treatment of Chronic Periodontitis: Randomized Controlled Clinical Trial. Eur J Dent. 2024 May;18(2):526-533. doi: 10.1055/s-0043-1772567. Epub 2023 Oct 17. PMID: 37848071; PMCID: PMC11132771.

Successful Management of Peri-Implantitis around Short and Ultrashort Single-Crown Implants: A Case Series with a 3-Year Follow-Up G. Lombardo, et al International Journal of Dentistry Volume 2019, Article ID 5302752.

Comparison of Different Chemical and Mechanical Decontamination Modalities on Titanium Dental Implants: Microbiological and Biocompatibility Analyses F. Citterio, et al., H.M. Goldman (2019)

Decontamination Using a Desiccant with Air Powder Abrasion Followed by Bi-Phasic Calcium Sulfate Grafting: a New Treatment for Peri-implantitis. G. Lombardo, et al. Case Reports in Dentistry. 2015.

The Treatment of Peri-Implant Diseases: A New Approach Using HYBENX® as a Decontaminant for Implant Surface and Oral Tissues. M. Lopez, et al. ORAL & Implant ology 9(3):106-114.2016.

The Effects of a New Decontaminant Solution on Root Canal Bleeding during Endodontic Treatment: A Randomized Controlled Study R. Pace, et al., J Biolog Reg & Homeo Agents. Vol. 33, no. 3 (S1), 1-9 (2019)

In Vitro Antimicrobial Activity of the Decontaminant HybenX® Compared to Chlorhexidine and Sodium Hypochlorite Against Common Bacterial and Yeast Pathogens A. Antonelli, et al. Antibiotics 2019, 8, 188.

Analysis of Dentinal Erosion and Removing Smear Layer of Different Irrigation Protocols: an In Vitro Study R. Pace, et al. G Ital Endod (2020) 34

In Vitro Alteration by Dentine and Protein of the Antimicrobial Activity of Two Endodontic Irrigants: HybenX® and Sodium Hypochlorite , et al. Antibiotics 2020, 9. 792.

Antimicrobial Activity of Sulfonated Phenolic Components in the Root Canal System. Systematic Review. K. Abud-Blanco, et al. Rev CSV. 7(2): 53-60. 2015.

New Conservative Approach for the Management of Recurrent
Sublingual Ranula—A Case Report Antonino Fiorino, et al. International Journal of Environmental Research and Public Health Jan 2023.

Single Application of a Desiccating Agent in the Treatment of Recurrent Aphthous Stomatitis. D. Lauritano, et al. J of Biologic Reg & Homes Agents. Vol. 29, no. 3(S1), 59-66 (2015).

An Alternative Approach for the Treatment of Major Aphthosis: Case Report. G. Nardi, et al. J Interdiscipl Med Dent Sci 2014, 2:5.

Randomized controlled trial of the efficacy of HybenX in the symptomatic treatment of recurrent aphthous stomatitis. S. Porter, et al. Oral Diseases (2009) 15, 155-161.